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“EXCELLENCE THROUGH KNOWLEDGE” P A G E 59 Extemporaneous Compounding of Captopril for Managing Cardiac Conditions in Children at a Major Paediatric Hospital in Jamaica Pediatric patients diagnosed with heart disease, specifically heart failure, are currently being managed with drug products developed for adult population rather than products based on evidence from clinical trials conducted in the population of interest. However, medicines used in the management of children may not be available in forms suitable for use in children. As such, drugs are used in an “off label” and unlicensed manner, requiring pharmacists (both in community and hospital) preparing “in house” or “extemporaneous” formulations mainly as solutions and suspensions to provide age-appropriate dosage forms for children using tablets and capsules as the source of the active ingredient. The inherent variability in quality of starting material and the compounding process suggest the need for evaluation of the extent of the practice and quality assessment of the products. The purpose of this study was to assess the extent of extemporaneous compounding and evaluate the quality and stability of select compounded products at a major children’s hospital in Jamaica using extemporaneous oral liquid - Captopril 3 mg/5mL as model formulation. Captopril had approximately 80 % of its doses manipulated before dispensing with dosing variations ranging from 0.5 to 15 mg. Tieca Harris; Sarafadeen Adebayo; Deon Bennett; O. Olugbuyi; & C. Scott PHARMACOLOGY & PHARMACEUTICS Editor’s Note: This research was published in The Caribbean Association of Pharmacist Magazine (CAP). DOI: 10.13140/2.1.3345.8248. Full Article available at: https://www.researchgate.net/publication/269991644.